Our research is concerned with the biology of mitotic and meiotic cell division. In particular, we study the genes involved in the regulation of these processes. As the regulatory mechanisms of the cell cycle have been highly conserved throughout evolution, we can learn a great deal of these processes through the study of model organisms such as yeasts and fruitflies that are amenable to experimental study. We can then extrapolate our findings to study the counterparts of the molecules we study in human cells. This allows us to examine their function both in normal cell division and in tumour cells.
Translational research is extremely important. How do we translate what we learn of the basic cell biology of cell division in organisms such as Drosophila to applications in the clinic? How do basic findings help us understand the causes of cancer and contribute to cancer therapy? Our own efforts in this direction are facilitated both through the technology arm of Cancer Research UK, who support some of our work to validate mitotic regulators as targets for therapy. We also have a long standing interaction with Cyclacel Ltd, a spin-out company from the University of Dundee. Information about Cancer Research Technology and Cyclacel Ltd can be found on their web sites.
The group is also a member of the Cambridge Cancer Centre that brings together all researchers in the University working on cancer. The main physical centres for this activity are in the Department of Oncology, the Hutchison/MRC Research Centre and the Cancer Research UK Cambridge Research Institute. This centralised activity links to numerous laboratories within the Schools of Biology and Medicine working on aspects of cancer research.
Richter, MM; Poznanski, J; Zdziarska, A; Czarnocki-Cieciura, M; Lipinszki, Z; Dadlez, M; Glover, DM; Przewloka, MR (2016)
Network of protein interactions within the Drosophila inner kinetochore.
Open Biology 6(2). PMID: 26911623
Coelho, PA; Bury, L; Shahbazi, MN; Liakath-Ali, K; Tate, PH; Wormald, S; Hindley, CJ; Huch, M; Archer, J; Skarnes, WC; Zernicka-Goetz, M; Glover, DM (2015)
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse
Open Biology vol. 5(12)
Prof. David Glover FRS, FRSE
Department of Genetics,
University of Cambridge,
+44 1223 333988
Dr. Crang (Lab Manager):
+44 1223 333986
+44 1223 333968